Drug interactions
Lormetazepam + Zolpidem
Severity: Major
Lormetazepam and Zolpidem: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are hypnotics acting on GABA-A receptors, so combining them raises the risk of excessive sedation, next-day impairment, falls and respiratory depression.
What this interaction means in plain words
Lormetazepam and Zolpidem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression via GABA-A receptor modulation.
What to do
Avoid using two hypnotics together. If unavoidable, use the lowest doses and monitor sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lormetazepam and Zolpidem, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Zolpidem
Frequently asked questions
Can I take Lormetazepam with Zolpidem?
MediHelp rates the interaction as major. Lormetazepam and Zolpidem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are hypnotics acting on GABA-A receptors, so combining them raises the risk of excessive sedation, next-day impairment, falls and respiratory depression.
How serious is the interaction between Lormetazepam and Zolpidem?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two hypnotics together. If unavoidable, use the lowest doses and monitor sedation.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
