Drug interactions
Lsd + Venlafaxine
Severity: Moderate
Lsd and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD is a serotonin receptor agonist, and combining it with venlafaxine can alter the response. Serotonin toxicity has been described with serotonergic drugs and hallucinogens, and the clinical picture may be unpredictable.
What this interaction means in plain words
Lsd and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Serotonergic pharmacodynamic interaction at 5-HT receptors, with possible altered LSD effect from chronic reuptake inhibition.
What to do
Advise patients to avoid LSD. If exposure occurs, monitor for serotonin syndrome, hypertension and tachycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Lsd with Venlafaxine?
MediHelp rates the interaction as moderate. Lsd and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. LSD is a serotonin receptor agonist, and combining it with venlafaxine can alter the response. Serotonin toxicity has been described with serotonergic drugs and hallucinogens, and the clinical picture may be unpredictable.
How serious is the interaction between Lsd and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid LSD. If exposure occurs, monitor for serotonin syndrome, hypertension and tachycardia.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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