Drug interactions
Lumacaftor / ivacaftor + Rabeprazole
Severity: Minor
Lumacaftor / ivacaftor and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor induces CYP enzymes including CYP2C19 and CYP3A4 while ivacaftor may inhibit CYP2C19, so net effects on rabeprazole are unpredictable. Because rabeprazole is mainly cleared non-enzymatically, the clinical effect is likely small.
What this interaction means in plain words
Lumacaftor / ivacaftor and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mixed induction and inhibition of CYP2C19 and CYP3A4 by lumacaftor/ivacaftor affects minor metabolic pathways of rabeprazole.
What to do
No dose adjustment is needed routinely. Monitor symptom control and adjust the PPI dose if acid suppression seems inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Rabeprazole?
MediHelp rates the interaction as minor. Lumacaftor / ivacaftor and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumacaftor induces CYP enzymes including CYP2C19 and CYP3A4 while ivacaftor may inhibit CYP2C19, so net effects on rabeprazole are unpredictable. Because rabeprazole is mainly cleared non-enzymatically, the clinical effect is likely small.
How serious is the interaction between Lumacaftor / ivacaftor and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed routinely. Monitor symptom control and adjust the PPI dose if acid suppression seems inadequate.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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