Drug interactions
Lumacaftor / ivacaftor + Tofacitinib
Severity: Moderate
Lumacaftor / ivacaftor and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a CYP3A inducer and may reduce tofacitinib exposure, which could reduce efficacy. Ivacaftor's weak CYP2C19 inhibition is unlikely to offset this and the net effect is uncertain.
What this interaction means in plain words
Lumacaftor / ivacaftor and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces CYP3A4, increasing tofacitinib clearance, partly offset by weak inhibition effects.
What to do
Monitor for reduced response to tofacitinib and consider an alternative if disease control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Tofacitinib?
MediHelp rates the interaction as moderate. Lumacaftor / ivacaftor and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a CYP3A inducer and may reduce tofacitinib exposure, which could reduce efficacy. Ivacaftor's weak CYP2C19 inhibition is unlikely to offset this and the net effect is uncertain.
How serious is the interaction between Lumacaftor / ivacaftor and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to tofacitinib and consider an alternative if disease control is lost.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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