Drug interactions
Lumefantrine + Pimozide
Severity: Contraindicated
Lumefantrine and Pimozide: contraindicated interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents prolong the QT interval, and combined use may lead to serious ventricular arrhythmias. This matters particularly because antimalarial treatment is often urgent.
What this interaction means in plain words
Lumefantrine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid; use an antimalarial without QT effects where possible. If unavoidable, withhold pimozide and monitor ECG and electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Lumefantrine with Pimozide?
MediHelp rates the interaction as contraindicated. Lumefantrine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong the QT interval, and combined use may lead to serious ventricular arrhythmias. This matters particularly because antimalarial treatment is often urgent.
How serious is the interaction between Lumefantrine and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; use an antimalarial without QT effects where possible. If unavoidable, withhold pimozide and monitor ECG and electrolytes.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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