Drug interactions
Lumefantrine + Zaleplon
Severity: Minor
Lumefantrine and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is reported to have weak effects on CYP3A4, and a small reduction in zaleplon exposure is theoretically possible. The interaction is not well characterized and is unlikely to matter, given zaleplon's reliance on aldehyde oxidase.
What this interaction means in plain words
Lumefantrine and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction by lumefantrine; the mechanism is not firmly established.
What to do
No action is needed beyond awareness; reassess if the hypnotic effect appears diminished.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Lumefantrine with Zaleplon?
MediHelp rates the interaction as minor. Lumefantrine and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine is reported to have weak effects on CYP3A4, and a small reduction in zaleplon exposure is theoretically possible. The interaction is not well characterized and is unlikely to matter, given zaleplon's reliance on aldehyde oxidase.
How serious is the interaction between Lumefantrine and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond awareness; reassess if the hypnotic effect appears diminished.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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