Drug interactions
Maitake + Methotrexate
Severity: Minor
Maitake and Methotrexate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maitake mushroom has immunostimulatory properties that could theoretically counteract methotrexate's immunosuppressive or antiproliferative effect. Clinical evidence is minimal and the direction of any effect is unclear.
What this interaction means in plain words
Maitake and Methotrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic opposition from immune stimulation; the mechanism is not established.
What to do
Ask patients about supplement use and monitor disease control. Consider advising against the supplement if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Maitake with Methotrexate?
MediHelp rates the interaction as minor. Maitake and Methotrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maitake mushroom has immunostimulatory properties that could theoretically counteract methotrexate's immunosuppressive or antiproliferative effect. Clinical evidence is minimal and the direction of any effect is unclear.
How serious is the interaction between Maitake and Methotrexate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about supplement use and monitor disease control. Consider advising against the supplement if control worsens.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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