Drug interactions
Marijuana + Propranolol
Severity: Minor
Marijuana and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis can cause tachycardia and orthostatic hypotension, and propranolol may blunt the heart rate rise while adding to blood pressure lowering. Cannabinoids may also modestly alter propranolol metabolism, but the clinical effect is poorly defined.
What this interaction means in plain words
Marijuana and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic cardiovascular effects; a possible minor pharmacokinetic effect on propranolol metabolism is not well established.
What to do
Counsel the patient about dizziness and orthostasis with cannabis use, and monitor heart rate and blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Marijuana with Propranolol?
MediHelp rates the interaction as minor. Marijuana and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabis can cause tachycardia and orthostatic hypotension, and propranolol may blunt the heart rate rise while adding to blood pressure lowering. Cannabinoids may also modestly alter propranolol metabolism, but the clinical effect is poorly defined.
How serious is the interaction between Marijuana and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about dizziness and orthostasis with cannabis use, and monitor heart rate and blood pressure.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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