Drug interactions
Measles mumps and rubella vaccine live + Rho human immunoglobulin
Severity: Moderate
Measles mumps and rubella vaccine live and Rho human immunoglobulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Passive antibodies in Rho(D) immune globulin can neutralize live MMR vaccine viruses and reduce the immune response. Protection may be inadequate.
What this interaction means in plain words
Measles mumps and rubella vaccine live and Rho human immunoglobulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Passively acquired antibodies neutralize replication of live vaccine viruses.
What to do
Delay MMR for about 3 months after Rho(D) immune globulin where possible. If given postpartum, check rubella and measles immunity after 3 months and revaccinate if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Measles mumps and rubella vaccine live with Rho human immunoglobulin?
MediHelp rates the interaction as moderate. Measles mumps and rubella vaccine live and Rho human immunoglobulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Passive antibodies in Rho(D) immune globulin can neutralize live MMR vaccine viruses and reduce the immune response. Protection may be inadequate.
How serious is the interaction between Measles mumps and rubella vaccine live and Rho human immunoglobulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay MMR for about 3 months after Rho(D) immune globulin where possible. If given postpartum, check rubella and measles immunity after 3 months and revaccinate if needed.
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