Drug interactions
Measles mumps rubella and varicella vaccine live + Rho human immunoglobulin
Severity: Moderate
Measles mumps rubella and varicella vaccine live and Rho human immunoglobulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibodies in Rho(D) immune globulin can neutralize the live viruses in MMRV vaccine and reduce immunogenicity. Protection against the vaccine-targeted diseases may be compromised.
What this interaction means in plain words
Measles mumps rubella and varicella vaccine live and Rho human immunoglobulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Passively acquired antibodies neutralize replication of live vaccine viruses.
What to do
Defer MMRV for about 3 months after Rho(D) immune globulin, or check immunity afterward and revaccinate if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Measles mumps rubella and varicella vaccine live with Rho human immunoglobulin?
MediHelp rates the interaction as moderate. Measles mumps rubella and varicella vaccine live and Rho human immunoglobulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibodies in Rho(D) immune globulin can neutralize the live viruses in MMRV vaccine and reduce immunogenicity. Protection against the vaccine-targeted diseases may be compromised.
How serious is the interaction between Measles mumps rubella and varicella vaccine live and Rho human immunoglobulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Defer MMRV for about 3 months after Rho(D) immune globulin, or check immunity afterward and revaccinate if needed.
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