Drug interactions
Measles vaccine + Rho human immunoglobulin
Severity: Moderate
Measles vaccine and Rho human immunoglobulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Passive antibodies in Rho(D) immune globulin can neutralize live measles vaccine virus and blunt the immune response. This may leave the recipient inadequately protected.
What this interaction means in plain words
Measles vaccine and Rho human immunoglobulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Passively acquired antibodies neutralize replication of the live vaccine virus.
What to do
Give measles-containing vaccine at least 3 months after Rho(D) immune globulin, or revaccinate or check immunity later. Postpartum rubella or MMR vaccination may be given with serologic follow-up at 3 months.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Measles vaccine with Rho human immunoglobulin?
MediHelp rates the interaction as moderate. Measles vaccine and Rho human immunoglobulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Passive antibodies in Rho(D) immune globulin can neutralize live measles vaccine virus and blunt the immune response. This may leave the recipient inadequately protected.
How serious is the interaction between Measles vaccine and Rho human immunoglobulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give measles-containing vaccine at least 3 months after Rho(D) immune globulin, or revaccinate or check immunity later. Postpartum rubella or MMR vaccination may be given with serologic follow-up at 3 months.
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