Drug interactions
Meclizine + Metoclopramide intranasal
Severity: Moderate
Meclizine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine has anticholinergic and sedating properties that oppose the prokinetic action of metoclopramide. Both drugs can also cause CNS effects such as drowsiness, and metoclopramide can cause extrapyramidal symptoms.
What this interaction means in plain words
Meclizine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism of gastric motility by anticholinergic effects, with additive CNS depression.
What to do
Avoid combining where possible, since the two have opposing effects on gastrointestinal motility. If both are needed, monitor for reduced metoclopramide efficacy, sedation and movement disorders.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Meclizine and Metoclopramide intranasal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Meclizine
Frequently asked questions
Can I take Meclizine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Meclizine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine has anticholinergic and sedating properties that oppose the prokinetic action of metoclopramide. Both drugs can also cause CNS effects such as drowsiness, and metoclopramide can cause extrapyramidal symptoms.
How serious is the interaction between Meclizine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, since the two have opposing effects on gastrointestinal motility. If both are needed, monitor for reduced metoclopramide efficacy, sedation and movement disorders.
What other medicines interact with Meclizine?
MediHelp also lists interactions of Meclizine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Meclizine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
