Drug interactions
Meclizine + Neomycin po
Severity: Minor
Meclizine and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine can suppress vertigo, tinnitus and nausea, which could mask early signs of aminoglycoside ototoxicity. Oral neomycin is poorly absorbed, so systemic ototoxicity is uncommon unless absorption is increased by renal impairment or damaged gut mucosa.
What this interaction means in plain words
Meclizine and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic masking of vestibular symptoms; no pharmacokinetic interaction.
What to do
Monitor hearing and renal function in patients with risk factors for neomycin absorption, and do not rely on symptoms alone while meclizine is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meclizine
Frequently asked questions
Can I take Meclizine with Neomycin po?
MediHelp rates the interaction as minor. Meclizine and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Meclizine can suppress vertigo, tinnitus and nausea, which could mask early signs of aminoglycoside ototoxicity. Oral neomycin is poorly absorbed, so systemic ototoxicity is uncommon unless absorption is increased by renal impairment or damaged gut mucosa.
How serious is the interaction between Meclizine and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hearing and renal function in patients with risk factors for neomycin absorption, and do not rely on symptoms alone while meclizine is used.
What other medicines interact with Meclizine?
MediHelp also lists interactions of Meclizine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Meclizine page.
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