Drug interactions
Meclofenamate + Perindopril
Severity: Moderate
Meclofenamate and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate, an NSAID, can blunt perindopril's blood pressure lowering effect and increases the risk of renal function decline. The risk is higher in older adults, volume depletion and chronic kidney disease.
What this interaction means in plain words
Meclofenamate and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandin synthesis reduces renal perfusion and counteracts ACE inhibitor effects.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Prefer paracetamol or the shortest NSAID course in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Meclofenamate with Perindopril?
MediHelp rates the interaction as moderate. Meclofenamate and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate, an NSAID, can blunt perindopril's blood pressure lowering effect and increases the risk of renal function decline. The risk is higher in older adults, volume depletion and chronic kidney disease.
How serious is the interaction between Meclofenamate and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Prefer paracetamol or the shortest NSAID course in at-risk patients.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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