Drug interactions
Meclofenamate + Prazosin
Severity: Minor
Meclofenamate and Prazosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can blunt the effect of antihypertensives through sodium and fluid retention. Blood pressure control with prazosin may be somewhat reduced.
What this interaction means in plain words
Meclofenamate and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of prostaglandin synthesis causes sodium retention and reduced vasodilation.
What to do
Monitor blood pressure when starting or stopping the NSAID. Adjust prazosin dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Meclofenamate with Prazosin?
MediHelp rates the interaction as minor. Meclofenamate and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs such as meclofenamate can blunt the effect of antihypertensives through sodium and fluid retention. Blood pressure control with prazosin may be somewhat reduced.
How serious is the interaction between Meclofenamate and Prazosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping the NSAID. Adjust prazosin dose if control worsens.
What other medicines interact with Prazosin?
MediHelp also lists interactions of Prazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Prazosin page.
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