Drug interactions
Meclofenamate + Propranolol
Severity: Moderate
Meclofenamate and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can blunt the antihypertensive effect of beta-blockers, particularly with sustained use. Blood pressure control may worsen, and renal function may be affected.
What this interaction means in plain words
Meclofenamate and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal and vascular prostaglandin synthesis causes sodium and water retention and vasoconstriction, opposing beta-blocker blood pressure lowering.
What to do
Monitor blood pressure when an NSAID is used for more than a few days, and use the lowest effective NSAID dose for the shortest time or consider paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Meclofenamate with Propranolol?
MediHelp rates the interaction as moderate. Meclofenamate and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamate can blunt the antihypertensive effect of beta-blockers, particularly with sustained use. Blood pressure control may worsen, and renal function may be affected.
How serious is the interaction between Meclofenamate and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when an NSAID is used for more than a few days, and use the lowest effective NSAID dose for the shortest time or consider paracetamol.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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