Drug interactions
Meclofenamate + Telmisartan
Severity: Moderate
Meclofenamate and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate can reduce the blood pressure lowering effect of telmisartan and impair renal function, particularly in elderly or volume-depleted patients. Hyperkalemia risk is also increased.
What this interaction means in plain words
Meclofenamate and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, and potassium retention is additive with ARB effects.
What to do
Monitor blood pressure, creatinine and potassium after starting the NSAID and periodically thereafter. Ensure hydration and use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Meclofenamate with Telmisartan?
MediHelp rates the interaction as moderate. Meclofenamate and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate can reduce the blood pressure lowering effect of telmisartan and impair renal function, particularly in elderly or volume-depleted patients. Hyperkalemia risk is also increased.
How serious is the interaction between Meclofenamate and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium after starting the NSAID and periodically thereafter. Ensure hydration and use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
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