Drug interactions
Meclofenamate + Tenofovir disoproxil
Severity: Moderate
Meclofenamate and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal perfusion and have been associated with acute kidney injury in patients receiving tenofovir. This may raise tenofovir levels and increase the risk of nephrotoxicity, especially with high or multiple NSAID doses.
What this interaction means in plain words
Meclofenamate and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-related reduction in renal blood flow plus competition for renal elimination, adding to tenofovir tubular toxicity.
What to do
Prefer non-NSAID analgesics such as paracetamol where possible. If an NSAID is needed, use the lowest dose for the shortest time and monitor serum creatinine and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Meclofenamate with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Meclofenamate and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal perfusion and have been associated with acute kidney injury in patients receiving tenofovir. This may raise tenofovir levels and increase the risk of nephrotoxicity, especially with high or multiple NSAID doses.
How serious is the interaction between Meclofenamate and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer non-NSAID analgesics such as paracetamol where possible. If an NSAID is needed, use the lowest dose for the shortest time and monitor serum creatinine and phosphate.
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