Drug interactions
Meclofenamate + Venlafaxine
Severity: Moderate
Meclofenamate and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine depletes platelet serotonin and impairs platelet aggregation, while meclofenamate, an NSAID, inhibits platelet function and damages gastric mucosa. Together the risk of gastrointestinal and other bleeding is increased.
What this interaction means in plain words
Meclofenamate and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet function by serotonin reuptake inhibition and COX inhibition, plus NSAID mucosal injury.
What to do
Avoid prolonged combined use where possible and consider gastroprotection with a proton pump inhibitor in high-risk patients. Monitor for melena, hematemesis and anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Meclofenamate with Venlafaxine?
MediHelp rates the interaction as moderate. Meclofenamate and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine depletes platelet serotonin and impairs platelet aggregation, while meclofenamate, an NSAID, inhibits platelet function and damages gastric mucosa. Together the risk of gastrointestinal and other bleeding is increased.
How serious is the interaction between Meclofenamate and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged combined use where possible and consider gastroprotection with a proton pump inhibitor in high-risk patients. Monitor for melena, hematemesis and anemia.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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