Drug interactions
Meningococcal a c y and w-135 polysaccharide vaccine combined + Methotrexate
Severity: Moderate
Meningococcal a c y and w-135 polysaccharide vaccine combined and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methotrexate may blunt the antibody response to meningococcal polysaccharide vaccine. Protection could be reduced in patients who are at risk of invasive disease.
What this interaction means in plain words
Meningococcal a c y and w-135 polysaccharide vaccine combined and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Methotrexate suppresses lymphocyte proliferation and humoral responses.
What to do
Vaccinate according to schedule and do not withhold the vaccine. Consider booster doses or antibody assessment in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Meningococcal a c y and w-135 polysaccharide vaccine combined with Methotrexate?
MediHelp rates the interaction as moderate. Meningococcal a c y and w-135 polysaccharide vaccine combined and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methotrexate may blunt the antibody response to meningococcal polysaccharide vaccine. Protection could be reduced in patients who are at risk of invasive disease.
How serious is the interaction between Meningococcal a c y and w-135 polysaccharide vaccine combined and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate according to schedule and do not withhold the vaccine. Consider booster doses or antibody assessment in high-risk patients.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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