Drug interactions
Meningococcal group b vaccine + Methotrexate
Severity: Moderate
Meningococcal group b vaccine and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methotrexate-related immunosuppression may reduce the response to meningococcal B vaccine. Protection may be less complete than in immunocompetent people.
What this interaction means in plain words
Meningococcal group b vaccine and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Methotrexate suppresses lymphocyte proliferation and humoral responses.
What to do
Complete the vaccine series on schedule, since vaccination remains advisable. Keep a high index of suspicion for meningococcal disease despite vaccination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Meningococcal group b vaccine with Methotrexate?
MediHelp rates the interaction as moderate. Meningococcal group b vaccine and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methotrexate-related immunosuppression may reduce the response to meningococcal B vaccine. Protection may be less complete than in immunocompetent people.
How serious is the interaction between Meningococcal group b vaccine and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the vaccine series on schedule, since vaccination remains advisable. Keep a high index of suspicion for meningococcal disease despite vaccination.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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