Drug interactions
Meningococcal group b vaccine + Thioguanine
Severity: Moderate
Meningococcal group b vaccine and Thioguanine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meningococcal group B vaccine is non-live, but thioguanine-related immunosuppression may reduce the antibody response. Protection may be incomplete.
What this interaction means in plain words
Meningococcal group b vaccine and Thioguanine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic-induced suppression of lymphocytes reduces vaccine immunogenicity.
What to do
Vaccinate before chemotherapy or after recovery of immune function where possible; if given during treatment, consider checking the response or revaccinating later.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioguanine
Frequently asked questions
Can I take Meningococcal group b vaccine with Thioguanine?
MediHelp rates the interaction as moderate. Meningococcal group b vaccine and Thioguanine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meningococcal group B vaccine is non-live, but thioguanine-related immunosuppression may reduce the antibody response. Protection may be incomplete.
How serious is the interaction between Meningococcal group b vaccine and Thioguanine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before chemotherapy or after recovery of immune function where possible; if given during treatment, consider checking the response or revaccinating later.
What other medicines interact with Thioguanine?
MediHelp also lists interactions of Thioguanine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Thioguanine page.
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