Drug interactions
Mepivacaine + Propranolol
Severity: Minor
Mepivacaine and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Local anesthetics can add to the hypotensive and negative chronotropic effects of beta-blockers, and systemic absorption of larger doses may cause bradycardia. Propranolol may also slightly reduce local anesthetic clearance. Clinically significant effects are uncommon at dental or infiltration doses.
What this interaction means in plain words
Mepivacaine and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mepivacaine belongs to Central Nervous System; Propranolol belongs to Cardiovascular.
Why it happens
Additive cardiovascular depression, with possible reduced hepatic clearance of the amide anesthetic.
What to do
Use the lowest effective mepivacaine dose and avoid intravascular injection. Monitor heart rate and blood pressure with larger doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Mepivacaine
- Bupivacaine implant + Mepivacaine Major
- Bupivacaine liposome + Mepivacaine Major
- Mepivacaine + Nadolol Moderate
- Mepivacaine + Timolol Moderate
- Hyaluronidase + Mepivacaine Minor
- Mepivacaine + Pindolol Minor
Frequently asked questions
Can I take Mepivacaine with Propranolol?
MediHelp rates the interaction as minor. Mepivacaine and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Local anesthetics can add to the hypotensive and negative chronotropic effects of beta-blockers, and systemic absorption of larger doses may cause bradycardia. Propranolol may also slightly reduce local anesthetic clearance. Clinically significant effects are uncommon at dental or infiltration doses.
How serious is the interaction between Mepivacaine and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective mepivacaine dose and avoid intravascular injection. Monitor heart rate and blood pressure with larger doses.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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