Drug interactions
Meprobamate + Olanzapine
Severity: Moderate
Meprobamate and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative-anxiolytic, and combined with olanzapine it can produce excessive drowsiness, impaired coordination and hypotension. Overdose or additional depressants raises the danger of respiratory depression.
What this interaction means in plain words
Meprobamate and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABAergic sedation from meprobamate and the sedating receptor profile of olanzapine.
What to do
Use the lowest doses and monitor sedation, blood pressure and falls risk. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Meprobamate with Olanzapine?
MediHelp rates the interaction as moderate. Meprobamate and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative-anxiolytic, and combined with olanzapine it can produce excessive drowsiness, impaired coordination and hypotension. Overdose or additional depressants raises the danger of respiratory depression.
How serious is the interaction between Meprobamate and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest doses and monitor sedation, blood pressure and falls risk. Avoid alcohol and other sedatives.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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