Drug interactions
Meprobamate + Topiramate
Severity: Moderate
Meprobamate and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative-anxiolytic that adds to topiramate's drowsiness and cognitive slowing. Together they can cause oversedation, impaired coordination and falls.
What this interaction means in plain words
Meprobamate and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from meprobamate and topiramate.
What to do
Use the lowest effective doses and monitor for sedation and impaired psychomotor function. Avoid alcohol and counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topiramate
Frequently asked questions
Can I take Meprobamate with Topiramate?
MediHelp rates the interaction as moderate. Meprobamate and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative-anxiolytic that adds to topiramate's drowsiness and cognitive slowing. Together they can cause oversedation, impaired coordination and falls.
How serious is the interaction between Meprobamate and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and impaired psychomotor function. Avoid alcohol and counsel on driving.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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