Drug interactions
Mercaptopurine + Ofatumumab sc
Severity: Moderate
Mercaptopurine and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells, and mercaptopurine suppresses lymphocytes and bone marrow function. Together they may produce additive immunosuppression and a higher risk of infection.
What this interaction means in plain words
Mercaptopurine and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic immunosuppression from B-cell depletion and antimetabolite activity.
What to do
Monitor for signs of infection and check blood counts periodically. Before starting ofatumumab in patients on or recently off immunosuppressants, consider the duration of effect of the prior therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Contraindicated
- Azathioprine + Mercaptopurine Contraindicated
- Bcg vaccine live + Mercaptopurine Contraindicated
- Febuxostat + Mercaptopurine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Contraindicated
- Mercaptopurine + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Mercaptopurine with Ofatumumab sc?
MediHelp rates the interaction as moderate. Mercaptopurine and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells, and mercaptopurine suppresses lymphocytes and bone marrow function. Together they may produce additive immunosuppression and a higher risk of infection.
How serious is the interaction between Mercaptopurine and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check blood counts periodically. Before starting ofatumumab in patients on or recently off immunosuppressants, consider the duration of effect of the prior therapy.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.
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