Drug interactions
Mercaptopurine + Rabies vaccine chick embryo cell derived
Severity: Moderate
Mercaptopurine and Rabies vaccine chick embryo cell derived: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mercaptopurine can reduce the immune response to this inactivated rabies vaccine, which may lead to inadequate protection. The vaccine is non-live, so the concern is poor response rather than infection from the vaccine.
What this interaction means in plain words
Mercaptopurine and Rabies vaccine chick embryo cell derived can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Immunosuppression impairs the development of an adaptive immune response to vaccine antigen.
What to do
Vaccinate when indicated and check rabies neutralizing antibody titers after the course. Give immune globulin when post-exposure prophylaxis is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mercaptopurine and Rabies vaccine chick embryo cell derived, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Contraindicated
- Azathioprine + Mercaptopurine Contraindicated
- Bcg vaccine live + Mercaptopurine Contraindicated
- Febuxostat + Mercaptopurine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Contraindicated
- Mercaptopurine + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Mercaptopurine with Rabies vaccine chick embryo cell derived?
MediHelp rates the interaction as moderate. Mercaptopurine and Rabies vaccine chick embryo cell derived can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mercaptopurine can reduce the immune response to this inactivated rabies vaccine, which may lead to inadequate protection. The vaccine is non-live, so the concern is poor response rather than infection from the vaccine.
How serious is the interaction between Mercaptopurine and Rabies vaccine chick embryo cell derived?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate when indicated and check rabies neutralizing antibody titers after the course. Give immune globulin when post-exposure prophylaxis is required.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
