Drug interactions
Mercaptopurine + Valoctocogene roxaparvovec
Severity: Moderate
Mercaptopurine and Valoctocogene roxaparvovec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valoctocogene roxaparvovec gene therapy commonly causes raised liver enzymes, and mercaptopurine is itself hepatotoxic. Combined use may increase the chance or severity of liver injury and affect the durability of gene expression.
What this interaction means in plain words
Mercaptopurine and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mercaptopurine belongs to Oncology; Valoctocogene roxaparvovec belongs to Miscellaneous.
Why it happens
Additive hepatotoxicity from two agents that can injure the liver.
What to do
Monitor liver enzymes closely and often during and after gene therapy. Consider an alternative to mercaptopurine if liver tests rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Contraindicated
- Azathioprine + Mercaptopurine Contraindicated
- Bcg vaccine live + Mercaptopurine Contraindicated
- Febuxostat + Mercaptopurine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Contraindicated
- Mercaptopurine + Smallpox vaccine live Contraindicated
Other interactions of Valoctocogene roxaparvovec
Frequently asked questions
Can I take Mercaptopurine with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Mercaptopurine and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec gene therapy commonly causes raised liver enzymes, and mercaptopurine is itself hepatotoxic. Combined use may increase the chance or severity of liver injury and affect the durability of gene expression.
How serious is the interaction between Mercaptopurine and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely and often during and after gene therapy. Consider an alternative to mercaptopurine if liver tests rise.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.
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