Drug interactions
Metformin + Methazolamide
Severity: Moderate
Metformin and Methazolamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methazolamide, a carbonic anhydrase inhibitor, causes metabolic acidosis and may add to the risk of metformin-associated lactic acidosis. This is of particular concern in patients with renal impairment or other risk factors.
What this interaction means in plain words
Metformin and Methazolamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbonic anhydrase inhibition reduces serum bicarbonate and causes hyperchloremic acidosis, compounding the acidosis risk with metformin.
What to do
Monitor acid-base status, serum bicarbonate and renal function during co-therapy. Consider stopping one of the drugs if acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Frequently asked questions
Can I take Metformin with Methazolamide?
MediHelp rates the interaction as moderate. Metformin and Methazolamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methazolamide, a carbonic anhydrase inhibitor, causes metabolic acidosis and may add to the risk of metformin-associated lactic acidosis. This is of particular concern in patients with renal impairment or other risk factors.
How serious is the interaction between Metformin and Methazolamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor acid-base status, serum bicarbonate and renal function during co-therapy. Consider stopping one of the drugs if acidosis develops.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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