Drug interactions
Metformin + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This regimen has no established pharmacokinetic interaction with metformin of major concern, but metformin exposure may rise modestly, and the risk of lactic acidosis is higher in patients with renal or hepatic impairment. Hepatitis C treatment also changes glycemic control as viral load falls.
What this interaction means in plain words
Metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not firmly established; possible transporter effects on metformin handling and changes in glucose metabolism during HCV clearance.
What to do
Monitor for symptoms of lactic acidosis and check renal function, and avoid metformin in significant renal or hepatic impairment. Monitor glucose, as hypoglycemia can emerge as HCV is cleared.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Frequently asked questions
Can I take Metformin with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This regimen has no established pharmacokinetic interaction with metformin of major concern, but metformin exposure may rise modestly, and the risk of lactic acidosis is higher in patients with renal or hepatic impairment. Hepatitis C treatment also changes glycemic control as viral load falls.
How serious is the interaction between Metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for symptoms of lactic acidosis and check renal function, and avoid metformin in significant renal or hepatic impairment. Monitor glucose, as hypoglycemia can emerge as HCV is cleared.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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