Drug interactions
Metformin + Perindopril
Severity: Minor
Metformin and Perindopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may slightly improve glucose control and reduce metformin requirements, and any acute renal impairment they cause can reduce metformin clearance. This raises a small risk of hypoglycemia with other agents and of lactic acidosis if renal function falls.
What this interaction means in plain words
Metformin and Perindopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin belongs to Endocrine; Perindopril belongs to Cardiovascular.
Why it happens
Improved insulin sensitivity and possible ACE inhibitor-related fall in renal function reducing metformin elimination.
What to do
Monitor renal function and glucose after starting perindopril. Hold metformin during acute illness with dehydration or declining renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Metformin
Frequently asked questions
Can I take Metformin with Perindopril?
MediHelp rates the interaction as minor. Metformin and Perindopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors may slightly improve glucose control and reduce metformin requirements, and any acute renal impairment they cause can reduce metformin clearance. This raises a small risk of hypoglycemia with other agents and of lactic acidosis if renal function falls.
How serious is the interaction between Metformin and Perindopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and glucose after starting perindopril. Hold metformin during acute illness with dehydration or declining renal function.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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