Drug interactions
Metformin + Phendimetrazine
Severity: Minor
Metformin and Phendimetrazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic that may raise blood glucose and alter insulin needs. Weight loss may in turn lower glucose and drug requirements.
What this interaction means in plain words
Metformin and Phendimetrazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Sympathomimetic activity can increase glycogenolysis, while appetite suppression changes glucose requirements; the net effect is variable.
What to do
Monitor blood glucose when phendimetrazine is started or stopped and adjust metformin if hypoglycemia or hyperglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin
Frequently asked questions
Can I take Metformin with Phendimetrazine?
MediHelp rates the interaction as minor. Metformin and Phendimetrazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phendimetrazine is a sympathomimetic anorectic that may raise blood glucose and alter insulin needs. Weight loss may in turn lower glucose and drug requirements.
How serious is the interaction between Metformin and Phendimetrazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when phendimetrazine is started or stopped and adjust metformin if hypoglycemia or hyperglycemia occurs.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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