Drug interactions
Metformin + Progesterone intravaginal
Severity: Minor
Metformin and Progesterone intravaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal progesterone gel results in low systemic exposure and is unlikely to significantly change glycemic control with metformin. Any effect is expected to be minimal.
What this interaction means in plain words
Metformin and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progesterone may slightly reduce insulin sensitivity, but systemic levels from intravaginal use are low.
What to do
No specific action is needed beyond routine glucose monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin
Frequently asked questions
Can I take Metformin with Progesterone intravaginal?
MediHelp rates the interaction as minor. Metformin and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal progesterone gel results in low systemic exposure and is unlikely to significantly change glycemic control with metformin. Any effect is expected to be minimal.
How serious is the interaction between Metformin and Progesterone intravaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine glucose monitoring.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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