Drug interactions
Metformin + Sulfamethoxypyridazine
Severity: Minor
Metformin and Sulfamethoxypyridazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibacterials have occasionally been linked to hypoglycemia, mainly with sulfonylureas. With metformin the risk is small, but additive glucose lowering is possible.
What this interaction means in plain words
Metformin and Sulfamethoxypyridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Sulfonamides may stimulate insulin secretion; the interaction with metformin is not well characterized.
What to do
Monitor glucose during sulfonamide therapy and counsel the patient on symptoms of hypoglycemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin
Frequently asked questions
Can I take Metformin with Sulfamethoxypyridazine?
MediHelp rates the interaction as minor. Metformin and Sulfamethoxypyridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfonamide antibacterials have occasionally been linked to hypoglycemia, mainly with sulfonylureas. With metformin the risk is small, but additive glucose lowering is possible.
How serious is the interaction between Metformin and Sulfamethoxypyridazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose during sulfonamide therapy and counsel the patient on symptoms of hypoglycemia.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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