Drug interactions
Metformin + Tenofovir df
Severity: Moderate
Metformin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir disoproxil is nephrotoxic in some patients, and reduced renal function can cause metformin accumulation and raise the risk of lactic acidosis. Pharmacokinetic effects on metformin itself are generally small.
What this interaction means in plain words
Metformin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tenofovir-related tubular injury can reduce renal clearance of metformin, which is eliminated unchanged by the kidney.
What to do
Monitor serum creatinine and eGFR regularly and stop or reduce metformin if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Frequently asked questions
Can I take Metformin with Tenofovir df?
MediHelp rates the interaction as moderate. Metformin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir disoproxil is nephrotoxic in some patients, and reduced renal function can cause metformin accumulation and raise the risk of lactic acidosis. Pharmacokinetic effects on metformin itself are generally small.
How serious is the interaction between Metformin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR regularly and stop or reduce metformin if renal function deteriorates.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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