Drug interactions
Metformin-sitagliptin + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Metformin-sitagliptin and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This regimen may alter metformin exposure and has been associated with glycemic changes as hepatitis C is treated. Metformin accumulation increases the risk of lactic acidosis, especially with renal or hepatic impairment.
What this interaction means in plain words
Metformin-sitagliptin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible inhibition of renal transporters (such as MATE/OCT2) may raise metformin exposure; the mechanism is not fully established.
What to do
Monitor for lactic acidosis symptoms and renal function. Avoid the combination in renal or hepatic impairment, and monitor glucose as hepatitis C is cleared.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Frequently asked questions
Can I take Metformin-sitagliptin with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Metformin-sitagliptin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This regimen may alter metformin exposure and has been associated with glycemic changes as hepatitis C is treated. Metformin accumulation increases the risk of lactic acidosis, especially with renal or hepatic impairment.
How serious is the interaction between Metformin-sitagliptin and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lactic acidosis symptoms and renal function. Avoid the combination in renal or hepatic impairment, and monitor glucose as hepatitis C is cleared.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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