Drug interactions
Metformin-sitagliptin + Progesterone intravaginal
Severity: Minor
Metformin-sitagliptin and Progesterone intravaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal progesterone gives low systemic exposure and any impact on glycemic control is expected to be small. A clinically relevant interaction is unlikely.
What this interaction means in plain words
Metformin-sitagliptin and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progesterone can reduce insulin sensitivity, but systemic exposure by this route is limited.
What to do
Monitor glucose if control changes after starting. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Frequently asked questions
Can I take Metformin-sitagliptin with Progesterone intravaginal?
MediHelp rates the interaction as minor. Metformin-sitagliptin and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal progesterone gives low systemic exposure and any impact on glycemic control is expected to be small. A clinically relevant interaction is unlikely.
How serious is the interaction between Metformin-sitagliptin and Progesterone intravaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose if control changes after starting. No routine dose change is needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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