Drug interactions
Metformin-sitagliptin + Progesterone micronized
Severity: Minor
Metformin-sitagliptin and Progesterone micronized: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral micronized progesterone may modestly reduce insulin sensitivity and glucose tolerance. The effect on glycemic control is usually small.
What this interaction means in plain words
Metformin-sitagliptin and Progesterone micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progesterone can reduce insulin sensitivity, mildly opposing antidiabetic action.
What to do
Monitor glucose when starting or stopping progesterone. Adjust therapy only if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Frequently asked questions
Can I take Metformin-sitagliptin with Progesterone micronized?
MediHelp rates the interaction as minor. Metformin-sitagliptin and Progesterone micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral micronized progesterone may modestly reduce insulin sensitivity and glucose tolerance. The effect on glycemic control is usually small.
How serious is the interaction between Metformin-sitagliptin and Progesterone micronized?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting or stopping progesterone. Adjust therapy only if control changes.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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