Drug interactions
Metformin-sitagliptin + Somatropin
Severity: Moderate
Metformin-sitagliptin and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone reduces insulin sensitivity and may raise blood glucose, reducing the effectiveness of metformin and sitagliptin. Diabetic patients may need higher antidiabetic doses after somatropin is started.
What this interaction means in plain words
Metformin-sitagliptin and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-sitagliptin belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Growth hormone induces insulin resistance and increases hepatic glucose output, opposing antidiabetic effects.
What to do
Monitor blood glucose frequently after starting or changing somatropin and adjust antidiabetic therapy accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Metformin-sitagliptin with Somatropin?
MediHelp rates the interaction as moderate. Metformin-sitagliptin and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone reduces insulin sensitivity and may raise blood glucose, reducing the effectiveness of metformin and sitagliptin. Diabetic patients may need higher antidiabetic doses after somatropin is started.
How serious is the interaction between Metformin-sitagliptin and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently after starting or changing somatropin and adjust antidiabetic therapy accordingly.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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