Drug interactions
Metformin-sitagliptin + Trifluoperazine
Severity: Moderate
Metformin-sitagliptin and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics may impair glucose tolerance and can reduce the glucose-lowering effect of metformin and sitagliptin. Control may shift when the antipsychotic is started or stopped.
What this interaction means in plain words
Metformin-sitagliptin and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antipsychotic-related insulin resistance and reduced insulin secretion oppose antidiabetic action.
What to do
Monitor blood glucose when starting, changing or stopping trifluoperazine. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Frequently asked questions
Can I take Metformin-sitagliptin with Trifluoperazine?
MediHelp rates the interaction as moderate. Metformin-sitagliptin and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazine antipsychotics may impair glucose tolerance and can reduce the glucose-lowering effect of metformin and sitagliptin. Control may shift when the antipsychotic is started or stopped.
How serious is the interaction between Metformin-sitagliptin and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, changing or stopping trifluoperazine. Adjust antidiabetic therapy as needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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