Drug interactions
Methotrexate + Methyclothiazide
Severity: Moderate
Methotrexate and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may reduce renal methotrexate clearance and have been reported to prolong myelosuppression with cytotoxic drugs. Volume depletion can also impair renal function. Methotrexate toxicity risk is greater with higher doses and renal impairment.
What this interaction means in plain words
Methotrexate and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion and volume depletion reduce methotrexate elimination.
What to do
Monitor blood counts and renal function, particularly with higher methotrexate doses. Reduce the methotrexate dose if cytopenias or a rise in creatinine occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Methotrexate with Methyclothiazide?
MediHelp rates the interaction as moderate. Methotrexate and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics may reduce renal methotrexate clearance and have been reported to prolong myelosuppression with cytotoxic drugs. Volume depletion can also impair renal function. Methotrexate toxicity risk is greater with higher doses and renal impairment.
How serious is the interaction between Methotrexate and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function, particularly with higher methotrexate doses. Reduce the methotrexate dose if cytopenias or a rise in creatinine occur.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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