Drug interactions
Methotrexate + Muromonab cd3
Severity: Major
Methotrexate and Muromonab cd3: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress immune function, and using them together deepens immunosuppression. This raises the risk of serious opportunistic and bacterial infections and may add to bone marrow suppression.
What this interaction means in plain words
Methotrexate and Muromonab cd3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic immunosuppression through T-cell depletion plus antimetabolite cytotoxicity.
What to do
Monitor for signs of infection and follow complete blood counts regularly. Reduce or review the doses of concurrent immunosuppressants and consider antimicrobial prophylaxis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Methotrexate with Muromonab cd3?
MediHelp rates the interaction as major. Methotrexate and Muromonab cd3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents suppress immune function, and using them together deepens immunosuppression. This raises the risk of serious opportunistic and bacterial infections and may add to bone marrow suppression.
How serious is the interaction between Methotrexate and Muromonab cd3?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and follow complete blood counts regularly. Reduce or review the doses of concurrent immunosuppressants and consider antimicrobial prophylaxis.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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