Drug interactions
Methotrexate + Mycophenolate
Severity: Moderate
Methotrexate and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining these immunosuppressants produces additive suppression of lymphocyte and bone marrow function. Patients face a higher risk of infection and cytopenias.
What this interaction means in plain words
Methotrexate and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiproliferative and immunosuppressive effects via inhibition of folate metabolism and of purine synthesis.
What to do
Monitor complete blood counts and for signs of infection. Lower the dose of one agent if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Methotrexate with Mycophenolate?
MediHelp rates the interaction as moderate. Methotrexate and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining these immunosuppressants produces additive suppression of lymphocyte and bone marrow function. Patients face a higher risk of infection and cytopenias.
How serious is the interaction between Methotrexate and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and for signs of infection. Lower the dose of one agent if cytopenias develop.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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