Drug interactions
Methotrexate + Neomycin po
Severity: Moderate
Methotrexate and Neomycin po: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin may reduce the absorption of oral methotrexate and can alter its enterohepatic cycling. This can lead to lower methotrexate exposure and possible loss of efficacy.
What this interaction means in plain words
Methotrexate and Neomycin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Neomycin-induced intestinal mucosal effects and gut flora changes reduce methotrexate absorption.
What to do
Monitor clinical response to methotrexate during oral neomycin courses. Consider separating doses or using parenteral methotrexate if efficacy appears reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Methotrexate with Neomycin po?
MediHelp rates the interaction as moderate. Methotrexate and Neomycin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral neomycin may reduce the absorption of oral methotrexate and can alter its enterohepatic cycling. This can lead to lower methotrexate exposure and possible loss of efficacy.
How serious is the interaction between Methotrexate and Neomycin po?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to methotrexate during oral neomycin courses. Consider separating doses or using parenteral methotrexate if efficacy appears reduced.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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