Drug interactions
Methotrexate + Pneumococcal vaccine polyvalent
Severity: Moderate
Methotrexate and Pneumococcal vaccine polyvalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methotrexate can blunt the antibody response to pneumococcal vaccination. Protection may be weaker than expected in treated patients.
What this interaction means in plain words
Methotrexate and Pneumococcal vaccine polyvalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Methotrexate suppresses lymphocyte proliferation needed for vaccine immune response.
What to do
Give the vaccine as indicated, because inactivated vaccines are still recommended. If disease control allows, consider timing the dose around a methotrexate hold per current guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Methotrexate with Pneumococcal vaccine polyvalent?
MediHelp rates the interaction as moderate. Methotrexate and Pneumococcal vaccine polyvalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methotrexate can blunt the antibody response to pneumococcal vaccination. Protection may be weaker than expected in treated patients.
How serious is the interaction between Methotrexate and Pneumococcal vaccine polyvalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine as indicated, because inactivated vaccines are still recommended. If disease control allows, consider timing the dose around a methotrexate hold per current guidance.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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