Drug interactions
Methotrexate + Poliovirus vaccine inactivated
Severity: Moderate
Methotrexate and Poliovirus vaccine inactivated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methotrexate may blunt the antibody response to inactivated poliovirus vaccine. The vaccine is safe to give, but protection may be suboptimal.
What this interaction means in plain words
Methotrexate and Poliovirus vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Methotrexate immunosuppression impairs antibody responses to vaccine antigens.
What to do
Give inactivated polio vaccine before methotrexate when possible. If given during therapy, consider serology or revaccination after immune recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Methotrexate with Poliovirus vaccine inactivated?
MediHelp rates the interaction as moderate. Methotrexate and Poliovirus vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methotrexate may blunt the antibody response to inactivated poliovirus vaccine. The vaccine is safe to give, but protection may be suboptimal.
How serious is the interaction between Methotrexate and Poliovirus vaccine inactivated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give inactivated polio vaccine before methotrexate when possible. If given during therapy, consider serology or revaccination after immune recovery.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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