Drug interactions
Methotrexate + Rituximab-hyaluronidase
Severity: Minor
Methotrexate and Rituximab-hyaluronidase: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rituximab is routinely combined with methotrexate, for example in rheumatoid arthritis, and no meaningful additive nephrotoxicity is established. The main concern is additive immunosuppression and infection risk, and tumor lysis-related renal injury applies only in malignancy.
What this interaction means in plain words
Methotrexate and Rituximab-hyaluronidase have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established pharmacokinetic mechanism; the main effect is additive immunosuppression rather than direct nephrotoxicity.
What to do
Monitor for infection and renal function as part of routine care. No dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Methotrexate with Rituximab-hyaluronidase?
MediHelp rates the interaction as minor. Methotrexate and Rituximab-hyaluronidase have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rituximab is routinely combined with methotrexate, for example in rheumatoid arthritis, and no meaningful additive nephrotoxicity is established. The main concern is additive immunosuppression and infection risk, and tumor lysis-related renal injury applies only in malignancy.
How serious is the interaction between Methotrexate and Rituximab-hyaluronidase?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and renal function as part of routine care. No dose change is needed.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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