Drug interactions
Methotrexate + Rose hips
Severity: Minor
Methotrexate and Rose hips: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rose hips contain salicylate-like acidic compounds and vitamin C that might compete with methotrexate for renal tubular secretion. Any rise in methotrexate levels is likely small but uncertain.
What this interaction means in plain words
Methotrexate and Rose hips have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical competition for renal tubular secretion of organic anions.
What to do
Avoid large intakes of rose hip supplements during high-dose methotrexate. Monitor for methotrexate toxicity if supplements are used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Methotrexate with Rose hips?
MediHelp rates the interaction as minor. Methotrexate and Rose hips have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rose hips contain salicylate-like acidic compounds and vitamin C that might compete with methotrexate for renal tubular secretion. Any rise in methotrexate levels is likely small but uncertain.
How serious is the interaction between Methotrexate and Rose hips?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid large intakes of rose hip supplements during high-dose methotrexate. Monitor for methotrexate toxicity if supplements are used regularly.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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