Drug interactions
Methotrexate + Sipuleucel-t
Severity: Moderate
Methotrexate and Sipuleucel-t: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sipuleucel-T depends on the patient's own immune cells mounting an antitumor response. Immunosuppressive agents such as methotrexate may blunt that response and reduce the benefit of the product.
What this interaction means in plain words
Methotrexate and Sipuleucel-t can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Methotrexate's immunosuppressive and antiproliferative actions may impair antigen-presenting cell activation and T-cell response to sipuleucel-T.
What to do
Avoid giving immunosuppressive doses of methotrexate around leukapheresis and infusions where possible. If it cannot be avoided, discuss the expected loss of benefit with the oncology team.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Methotrexate with Sipuleucel-t?
MediHelp rates the interaction as moderate. Methotrexate and Sipuleucel-t can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sipuleucel-T depends on the patient's own immune cells mounting an antitumor response. Immunosuppressive agents such as methotrexate may blunt that response and reduce the benefit of the product.
How serious is the interaction between Methotrexate and Sipuleucel-t?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving immunosuppressive doses of methotrexate around leukapheresis and infusions where possible. If it cannot be avoided, discuss the expected loss of benefit with the oncology team.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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