Drug interactions
Methotrexate + Streptozocin
Severity: Major
Methotrexate and Streptozocin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidney, and combined use increases the chance of renal impairment. Reduced renal function in turn slows methotrexate elimination and raises its toxicity.
What this interaction means in plain words
Methotrexate and Streptozocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity, with reduced renal clearance of methotrexate.
What to do
Monitor serum creatinine and electrolytes closely and ensure hydration. Consider methotrexate levels and dose reduction if renal function declines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Methotrexate with Streptozocin?
MediHelp rates the interaction as major. Methotrexate and Streptozocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can injure the kidney, and combined use increases the chance of renal impairment. Reduced renal function in turn slows methotrexate elimination and raises its toxicity.
How serious is the interaction between Methotrexate and Streptozocin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and electrolytes closely and ensure hydration. Consider methotrexate levels and dose reduction if renal function declines.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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